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Bibliografia sobre menopausa
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Premenopausal overweight women do not lose bone during
moderate weight loss with adequate or higher calcium intake.
Riedt CS,
Schlussel Y,
von Thun N,
Ambia-Sobhan H,
Stahl T,
Field MP,
Sherrell RM,
Shapses SA.
Rutgers University, New Brunswick, NJ, USA.
BACKGROUND: Weight loss is associated with bone loss, but this has not been
examined in overweight premenopausal women. OBJECTIVE: The aim of this study
was to assess whether overweight premenopausal women lose bone with moderate
weight loss at recommended or higher than recommended calcium intakes.
DESIGN: Overweight premenopausal women [n = 44; x (+/-SD) age: 38 +/- 6.4 y;
body mass index (BMI): 27.7 +/- 2.1 kg/m(2)] were randomly assigned to
either a normal (1 g/d) or high (1.8 g/d) calcium intake during 6 mo of
energy restriction [weight loss (WL) groups] or were recruited for weight
maintenance at 1 g Ca/d intake. Regional bone mineral density and content
were measured by dual-energy X-ray absorptiometry, and markers of bone
turnover were measured before and after weight loss. True fractional calcium
absorption (TFCA) was measured at baseline and during caloric restriction by
using a dual-stable calcium isotope method. RESULTS: The WL groups lost 7.2
+/- 3.3% of initial body weight. No significant decrease in BMD or rise in
bone turnover was observed with weight loss at normal or high calcium intake.
The group that consumed high calcium showed a strong relation (r = 0.71)
between increased femoral neck bone mineral density and increased serum 25-hydroxyvitamin
D. No significant effect of weight loss on TFCA was observed, and the total
calcium absorbed was adequate at 238 +/- 81 and 310 +/- 91 mg/d for the
normal- and high-calcium WL groups, respectively. CONCLUSION: Overweight
premenopausal women do not lose bone during weight loss at the recommended
calcium intake, which may be explained by sufficient amounts of absorbed
calcium.
Publication Types:
PMID: 17413095 [PubMed - indexed for MEDLINE]