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Bibliografia sobre menopausa

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Diet assessment and the screening for osteoporosis: a survey in a healthy menopause population.

Bianco V, Filippi F, Tassan-Simonat P, Valente I, D'Amico C, Meroni M.

Second Obstetrics and Gynecological Clinic University of Milan, Milan, Italy vanda.bianco@unimi.it.

AIM: The aim of this study was to investigate about diet assessment in the screening for osteoporosis. METHODS: In 1 441 women (group A, mean age 53.5 years, mean time from menopause 3.92(+/-4.33)] the number of daily/weekly servings/cups of different foods has been collected. In 71 women (group B, mean age 59 years, mean time from menopause 6 years) diet was assessed through a detailed questionnaire. Demographic and clinical data and dietary habits were related to bone mineral density (BMD) values, using Student t-test and the c2 test. RESULTS: Group A: borderline/reduced BMD 40%, the percentage increasing with age and the duration of menopause (P<0.001). BMI within normal range 56.28%. BMD values were positively associated with Body Mass Index (BMI, P<0.001), education level (P<0.005), job (P<0.01), oral contraceptives use (P<0.001), negatively with family history of osteoporosis (P<0.05). BMD values showed a positive relation with the number of eggs per week (P<0.05), positive not significant trends were observed with dairy products, vegetables, red and white meat intake. A low/reduced BMD was related to low calcium food intake in less than 50% of the women. Group B: borderline/reduced BMD 55%; BMD showed positive trends, not significant, with daily calcium intake, BMI, physical exercise. Estimated calcium intake less than 700 mg/day was found in 33% of the sample. CONCLUSION: Diet assessment is not useful in the screening for osteoporosis. In women with borderline or reduced BMD, diet assessment helps to detect those at low calcium intake who need calcium supplementation, alone or in combination with other treatments.

PMID: 18560345 [PubMed - in process]

 
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How much do the Arab females know about osteoporosis? The scope and the sources of knowledge.

Al Attia HM, Abu Merhi AA, Al Farhan MM.

Department of Internal Medicine and Rheumatology, Mafraq Hospital, Abu Dhabi, United Arab Emirates, haideralattia@hotmail.com.

Three hundred fifty-eight educated women, 172 with secondary school education (49%) and 186 (51%) with higher education, were consented for the study. Eighty-five percent were Arab females with an average age of 28.8 years. They expressed their knowledge on osteoporosis on one-one interview. A score of two or more correct items would qualify the respondents to indicate the source(s) of their knowledge. Highly educated women had significantly less 0-1 score (37/186, 20%) than the other subgroup (74/172, 44%, p = 0.001). They, on average, expressed 2.5 items of knowledge vs. 1.69 by the other subgroup (p = 0.002). A total of 245 females, then, became eligible to indicate the source of knowledge. Osteoporosis as a "disease of menopause women" (84%) followed by "disease of easily fractured bones" (64.5%) were the highest in the list in their perception collectively and individually. Items relevant to lifestyle habits, complications, and disease associations were identically not acknowledged. They, however, significantly differed in their response to two items: "a disease of low bone density" and the "role of immobilization and low exercise." Highly educated women appeared more respondent than the other group (p = 0.008 and p = 0.05, respectively). Both were dependent on the "visual media," "relatives," and the "medics" as main sources of information. "Reading books" and "listening to radio programs" on osteoporosis were never considered. The highly educated Arab females have excelled over others with secondary education in terms of frequency and averaging the items of knowledge on osteoporosis. They, however, were not different in the way they perceived osteoporosis as well as in indicating their sources of knowledge. The results reemphasize the lack of an international standard in the understanding of osteoporosis among different populations of females.

PMID: 18516658 [PubMed - as supplied by publisher]

 
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Results of a diet/exercise feasibility trial to prevent adverse body composition change in breast cancer patients on adjuvant chemotherapy.

Demark-Wahnefried W, Case LD, Blackwell K, Marcom PK, Kraus W, Aziz N, Snyder DC, Giguere JK, Shaw E.

Department of Behavioral Sciences, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA. wdemarkw@mdanderson.org

PURPOSE: Patients with breast cancer on adjuvant chemotherapy can experience weight gain and concurrent losses in muscle mass. Exercise interventions can prevent these changes, but time and travel pose barriers to participation. The Survivor Training for Enhancing Total Health (STRENGTH) trial assessed the feasibility and impact of 2 home-based interventions. PATIENTS AND METHODS: Ninety premenopausal patients with breast cancer on adjuvant chemotherapy were randomized to a calcium-rich diet (CA) intervention (attention control) or to 2 experimental arms: a CA + exercise (EX) arm or a CA + EX and high fruit and vegetable, low-fat diet (FVLF) arm. Exercise arms included aerobic and strength-training exercises. Body composition, weight status, waist circumference, dietary intake, physical activity, quality of life, anxiety, depression, serum lipids, sex hormone binding globulin, insulin, proinsulin, C-reactive protein, interleukin-1B, and tumor-necrosis factor receptor-II were measured at baseline and at 6-month follow-up. RESULTS: Accrual targets were achieved and modest attrition was observed (8.8%). Self-reports suggest increased calcium intakes in all arms, and higher fruit and vegetable and lower fat intake in the CA + EX + FVLF arm; no differences in physical activity were observed. While measures of adiposity were generally lower in the CA + EX + FVLF arm, the only significant difference was in percentage of body fat (arms and legs); change in scores (mean +/- standard deviation) were +0.7% +/- 2.3% (CA); +1.2% +/- 2.7% (CA + EX); and +0.1% +/- 2% (CA + EX + FVLF; P = .047). Lean body mass was largely preserved, even in the control arm (net gain of 452 g +/- 2395 g). No differences were observed in other endpoints. CONCLUSION: Diet and exercise interventions can prevent weight gain and adverse body composition changes, but more research is needed to determine optimally effective interventions that can be implemented during active treatment and that promote adherence.

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PMID: 18501061 [PubMed - indexed for MEDLINE]


 
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A prospective study of age-specific physical activity and premenopausal breast cancer.

Maruti SS, Willett WC, Feskanich D, Rosner B, Colditz GA.

Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M4-B402, Seattle, WA 98109-1024, USA. smaruti@fhcrc.org

BACKGROUND: Physical activity has been consistently associated with lower risk of postmenopausal breast cancer, but its relationship with premenopausal breast cancer is unclear. We investigated whether physical activity is associated with reduced incidence of premenopausal breast cancer, and, if so, what age period and intensity of activity are critical. METHODS: A total of 64,777 premenopausal women in the Nurses' Health Study II reported, starting on the 1997 questionnaire, their leisure-time physical activity from age 12 to current age. Cox regression models were used to examine the relationship between physical activity, categorized by age period (adolescence, adulthood, and lifetime) and intensity (strenuous, moderate, walking, and total), and risk of invasive premenopausal breast cancer. RESULTS: During 6 years of follow-up, 550 premenopausal women developed breast cancer. The strongest associations were for total leisure-time activity during participants' lifetimes rather than for any one intensity or age period. Active women engaging in 39 or more metabolic equivalent hours per week (MET-h/wk) of total activity on average during their lifetime had a 23% lower risk of premenopausal breast cancer (relative risk = 0.77; 95% confidence interval = 0.64 to 0.93) than women reporting less activity. This level of total activity is equivalent to 3.25 h/wk of running or 13 h/wk of walking. The age-adjusted incidence rates of breast cancer for the highest (> or = 54 MET-h/wk) and lowest (< 21 MET-h/wk) total lifetime physical activity categories were 136 and 194 per 100 000 person-years, respectively. High levels of physical activity during ages 12-22 years contributed most strongly to the association. CONCLUSIONS: Leisure-time physical activity was associated with a reduced risk for premenopausal breast cancer in this cohort. Premenopausal women regularly engaging in high amounts of physical activity during both adolescence and adulthood may derive the most benefit.

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PMID: 18477801 [PubMed - indexed for MEDLINE]


 
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Quality of life in obese postmenopausal women.

Jones GL, Sutton A.

Health Services Research Section, ScHARR, Sheffield, UK. G.L.Jones@sheffield.ac.uk

The aim of this review was to identify the ways in which obesity affects the health-related quality of life (HRQoL) of postmenopausal women. This was considered important because a growing body of literature has identified obesity as a significant predictor for a poor psychological wellbeing and negative HRQoL, particularly in women, and because during the transition through the menopause women tend to accumulate more body weight. After searching eight electronic databases, only nine papers appeared meaningful. Although a meta-analysis was not possible, we found that a body mass index (BMI) > 30 kg/m2 was associated with a poor HRQoL in postmenopausal women; particularly in the areas associated with physical functioning, energy and vitality, and health perceptions. Thus, clinical management of obese postmenopausal women should focus on weight reduction and exercise in an attempt to improve wellbeing in these areas. However, the paucity of research, the different instruments chosen to measure HRQoL and the methodological limitations of the studies identified, prevented firm conclusions being made about whether the relationship between BMI and HRQoL is linear in postmenopausal women. Further research is needed to explore this relationship; particularly in comparison with underweight postmenopausal women and obese premenopausal women, where a few papers have identified these women as having a worse HRQoL than their obese postmenopausal counterparts. Other measures of central adiposity, including waist circumference and waist-hip ratio are recommended as useful supplemental measures to BMI in future studies.

PMID: 18380958 [PubMed - in process]

 
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Physical activity and mammographic density in a cohort of midlife women.

Oestreicher N, Capra A, Bromberger J, Butler LM, Crandall CJ, Gold EB, Greendale GA, Modugno F, Sternfeld B, Habel LA.

Kaiser Permanente Division of Research, Oakland, CA 94612, USA.

PURPOSE: Physical activity (PA) is one of few modifiable breast cancer risk factors. There have been few studies of the relation between PA and mammographic density, especially in multiethnic populations. METHODS: In a cohort of pre- and early perimenopausal women of non-Hispanic white (N = 373), African American (N = 55), Chinese (N = 178), and Japanese (N = 166) ethnicity, we used multivariable linear regression to examine the association between two measures of mammographic density (percent density and area of density) and mutually exclusive components of recent physical activity (sports, household/caregiving and work activity, active living). RESULTS: After adjusting for race/ethnicity, menopausal status, parity, past use of hormones, body mass index, waist circumference and education, we observed nonsignificant inverse associations for percent mammographic density and the highest versus the lowest category of each of our PA domains. For example, the adjusted beta for active living = -2.62, 95% confidence interval (CI) (-5.84, 0.60). Nonsignificant inverse associations also were observed for area of density and each PA domain except work activity. However, most associations were nonlinear. CONCLUSION: Our results are consistent with a modest inverse association between multiple domains of PA and mammographic density, although findings may have been attributable to chance alone.

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PMID: 18379206 [PubMed - indexed for MEDLINE]


 
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Effect of exercise on rate pressure product in premenopausal and postmenopausal women with coronary artery disease.

Nagpal S, Walia L, Lata H, Sood N, Ahuja GK.

Department of Physiology, Dayanand Medical College and Hospital, Ludhiana.

Incidence of coronary artery disease (CAD) increases sharply after menopause in women. Rate pressure product (RPP) is a major determinant of cardiac oxygen consumption. It is an important indicator of ventricular function. RPP varies with exercise. The peak rate pressure product (PRPP) which gives an accurate reflection of the myocardial oxygen demand and myocardial workload is the RPP at peak of exercise. The higher the PRPP, the more will be myocardial oxygen consumption (MVO2). The ability to reach higher PRPP is associated with more adequate coronary perfusion. Thus the low value of PRPP suggests significant compromise of coronary perfusion and decreased left ventricular function. In the present study effect of exercise on RPP of pre and postmenopausal women with CAD was compared. The percentage increase in RPP was significantly more in postmenopausal women with CAD (62%) as compared to premenopausal women with CAD (54%) indicating more compromised coronary perfusion in postmenopausal women.

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PMID: 18341225 [PubMed - indexed for MEDLINE]


 
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Role of exercise in osteoporosis prevention--current concepts.

Hingorjo MR, Syed S, Qureshi MA.

Department of Physiology, Fatima Jinnah Dental College, Karachi.

Osteoporosis is a metabolic disorder of the bones due to loss of both bone mineral and bone matrix in equal proportions resulting in a bone that is weak and unable to support the body. This becomes a problem in the elderly who are then at risk of frequent fractures increasing the morbidity and mortality. Measures taken early in life in the form of calcium and exercise go far in preventing the development of this disorder. The primary purpose of this narrative review is to evaluate the current literature and to provide insight into the role of exercise relating to osteoporosis. Emphasis is given to the importance of the specific types of exercises needed to increase bone strength and muscle power, keeping in view the age and general physical condition of the person.

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PMID: 18333526 [PubMed - indexed for MEDLINE]


 
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Physical activity and fracture risk: a prospective study of 1898 incident fractures among 34,696 British men and women.

Appleby PN, Allen NE, Roddam AW, Key TJ.

Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, OX3 7LF, UK. paul.appleby@ceu.ox.ac.uk

Regular physical activity is believed to have a beneficial effect on bone health but may also increase the risk of fractures by increasing the incidence of injury. We examined the association between physical activity and fracture risk in a prospective study of self-reported incident fractures among 34 696 men and women aged 20 to 89 years in the United Kingdom. Over an average of 5.2 years of follow-up, 343 men and 1555 women reported one or more fractures. For the 72% of fractures caused by a fall, the only significant association with physical activity was the lower fracture rate among women with a standing occupation compared with women in sedentary or no employment [incidence rate ratio, 0.81 (95% CI, 0.69-0.95)]. There was a strong positive association between bicycling and fracture risk: P < 0.001 for trend for both sexes. Regular participation in exercise and sports other than walking and bicycling was also associated with an increased fracture risk, and fracture rates were significantly higher for male manual workers compared with men in sedentary or no employment. These positive associations of physical activity with fracture risk applied primarily to fractures not caused by a fall. The relatively low fracture risk among women with a standing occupation might be the result of a beneficial effect of weight-bearing exercise. The markedly increased risk of fractures associated with bicycling, and the moderately increased risk associated with other exercise and sports, are probably the result of an increased incidence of injury.

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PMID: 18301977 [PubMed - indexed for MEDLINE]


 
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Effects of additional resistance training during diet-induced weight loss on bone mineral density in overweight premenopausal women.

Nakata Y, Ohkawara K, Lee DJ, Okura T, Tanaka K.

Institute of Health and Sport Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305-8577, Japan. nakata@stat.taiiku.tsukuba.ac.jp

Bone loss accompanies a diet-induced weight loss and could be prevented with a combination of exercises. This study was conducted to examine the effects of additional resistance training during diet-induced weight loss on whole-body and selected regional bone mineral density (BMD). The participants of a 14-week weight-loss study were 42 overweight premenopausal Japanese women who were randomly placed in either a diet-only group (D; n = 21) or a diet plus resistance training group (DR; n = 21). Whole-body BMD and body composition, lumbar spine BMD, and 1/3 radial BMD were measured by dual-energy X-ray absorptiometry before and after the intervention. Bone formation and resorption markers were also measured. Thirty-five participants (83%) completed the study. Individuals in groups D (n = 17) and DR (n = 18) lost 6.2 +/- 3.5 kg and 8.6 +/- 3.6 kg body weight, respectively. Reductions in percentage fat mass and fat mass in group DR were significantly greater than in group D; lean mass decreased significantly in both groups. The effect of time on whole-body BMD was significant (-0.3%); however, whole-body bone mineral content, lumbar spine BMD, and 1/3 radial BMD remained unchanged. There were no significant timeby-group interactions in the whole-body and regional BMD and bone markers. These results suggest that additional resistance training during weight loss has no effect on BMD in overweight premenopausal Japanese women. Further long-term studies with large numbers of subjects are needed.

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PMID: 18301974 [PubMed - indexed for MEDLINE]


 
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A moderate-intensity exercise program fulfilling the American College of Sports Medicine net energy expenditure recommendation improves health outcomes in premenopausal women.

Dalleck LC, Borresen EC, Wallenta JT, Zahler KL, Boyd EK.

Department of Kinesiology, University of Wisconsin-Eau Claire, Eau Claire, Wisconsin, USA. dalleclc@uwec.edu

The purpose of this study was to assess and quantify the health outcomes associated with a moderate-intensity (50% VO2R) exercise program designed to achieve the American College of Sports Medicine net caloric expenditure guideline of 1,000 kcal x wk(-1). Fifteen apparently healthy but sedentary premenopausal women with the baseline characteristics (mean +/- SD age, height, weight, body composition, and VO2max: 37.4 +/- 6.3 yr, 166.2 +/- 6.2 cm, 72.1 +/- 11.2 kg, 32.5 +/- 5.8%, and 34.8 +/- 5.8 mL x kg(-1) x min(-1), respectively) participated in and completed the study. Exercise training was performed 3-4 days per week for 10 weeks in a progressive manner at moderate intensity (50% VO2R). There were significant (P < 0.05) improvements in VO2max (+2.5 mL x kg(-1) x min(-1)), systolic (-13.7 mm Hg) and diastolic (-6.4 mm Hg) blood pressure, high-density lipoprotein cholesterol (+3.2 mg x dL(-1)), fasting blood glucose (-4.9 mg x dL(-1)), and percent body fat (-1.6%). Although the American College of Sports Medicine specifies that the energy expenditure goal should be a net caloric expenditure of 1,000 kcal x wk(-1) and classifies relative moderate intensity as 40-59% of heart rate reserve or VO2R, we are unaware of any previous investigations that have examined the specific health outcomes associated with an exercise program fulfilling these requirements. Results indicate that significant health benefits will be conferred to previously sedentary, premenopausal women who engage in a moderate-intensity, 10-week exercise program designed to fulfill the net energy expenditure guideline of 1,000 kcal x wk(-1).

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PMID: 18296984 [PubMed - indexed for MEDLINE]


 
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Influence of calcium intake and physical activity on proximal femur bone mass and structure among pre- and postmenopausal women. A 10-year prospective study.

Uusi-Rasi K, Sievänen H, Pasanen M, Beck TJ, Kannus P.

The UKK Institute, P.O. Box 30, 33501 Tampere, Finland. kirsti.uusi-rasi@uta.fi

This 10-year follow-up evaluated the effect of physical activity and calcium intake on proximal femur bone mass (BMC) and structural indices (CSA and Z) and physical performance. A cohort of 133 premenopausal and 134 postmenopausal women with contrasting levels of physical activity (high [PA+]) and low [PA-]) and calcium intake (high [Ca+] and low [Ca-]) was measured with DXA at baseline and 5 and 10 years thereafter. Among premenopausal women, the mean (95% CI) femoral neck BMC was 3.8% (-0.1 to 7.8%) and the trochanter BMC 6.7% (2.4 to 11.3%) greater in the PA+ group than the PA- group. There was no difference between the Ca-intake groups. Among postmenopausal women, the mean femoral neck BMC was 4.2% (-0.2 to 8.8%) greater in the Ca+ group than in the Ca- group and 6.9% (2.2 to11.8%) greater in the PA+ group than in the PA- group. For trochanter BMC, the corresponding differences were 2.7% (-1.6 to 7.2%) and 5.5% (0.9 to 10.3%). The mean differences in CSA and Z were 3.8% (-0.9 to 8.7%) and 4.4% (-2.1 to 11.4%) in favor of the Ca+ group and 6.8% (1.9 to 12.0%) and 9.6% (2.5 to 17.1%) in favor of the PA+ group, respectively. Proximal femur BMC declined generally, but the initial differences between the physical activity and the calcium intake groups were maintained. High calcium intake seemed to slow the decline in trochanter BMC in premenopausal women, while high physical activity was beneficial for proximal femur, particularly among older women.

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PMID: 18270646 [PubMed - indexed for MEDLINE]


 
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Treatment and prevention of osteoporosis.

Blahos J.

Endocrine Unit and Osteocentre, Central Military Hospital, Prague, Czech Republic. blahos@cls.cz

Osteoporosis is recognized as a major health threat. The number of patients will certainly grow with the aging of the population. While preventive strategies, such as calcium, vitamin D, exercise and reduced risk factors may diminish the impact of menopause and age-regulated bone loss, many patients will become candidates for pharmacologic therapy. A variety of options are available, including HRT, bisphosphonates, SERMs, calcitonin, strontium ranelate, teriparatid. New forms of treatment are appearing on the horizon, such as monoclonal antibodies, nitrates, beta-blockers and Cathepsin K inhibitors.

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PMID: 18204959 [PubMed - indexed for MEDLINE]


 
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Centrally located body fat is related to inflammatory markers in healthy postmenopausal women.

Perry CD, Alekel DL, Ritland LM, Bhupathiraju SN, Stewart JW, Hanson LN, Matvienko OA, Kohut ML, Reddy MB, Van Loan MD, Genschel U.

From the 1Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA; 2School of Health, Physical Education, and Leisure Services, University of Northern Iowa, Cedar Falls, IA; 3Department of Kinesiology, Iowa State University, Ames, IA; 4U.S. Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA; and 5Department of Statistics, Iowa State University, Ames, IA.

OBJECTIVE:: C-reactive protein and fibrinogen are established atherosclerotic cardiovascular disease risk factors. These acute-phase proteins and the proinflammatory cytokines tumor necrosis factor alpha, interleukin-6, and interleukin-1beta may be elevated in obesity and with menopause. The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women. DESIGN:: We used dual-energy x-ray absorptiometry to assess overall and regional body composition (fat mass in particular) in 242 postmenopausal women in relation to plasma fibrinogen, serum C-reactive protein, and these proinflammatory cytokines. RESULTS:: Multiple regression analyses revealed that 36% of the variability in C-reactive protein (F = 32.4, P </= 0.0001) was accounted for by androidal fat mass (16.1%, P </= 0.0001), white blood cells (5.6%, P </= 0.0001), and age (2.3%, P = 0.0045). Regression analyses revealed that 30% of the variability in fibrinogen (F = 24.5, P </= 0.0001) was accounted for by white blood cells (3.1%, P = 0.0015), hip fat mass (2.2%, P = 0.0081), years since menopause (0.9%, P = 0.082), and geographic site (P </= 0.0001). Our results indicated that androidal fat mass and hip fat mass contributed to C-reactive protein and fibrinogen, respectively, whereas we found no association between whole-body or regional fat measures and cytokines. CONCLUSION:: Further study is warranted to determine the responsiveness of these acute-phase proteins and cytokines to loss of body fat through exercise and dietary intervention in postmenopausal women.

PMID: 18202591 [PubMed - as supplied by publisher]

 
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Exercise effect on oxidative stress is independent of change in estrogen metabolism.

Schmitz KH, Warren M, Rundle AG, Williams NI, Gross MD, Kurzer MS.

Division of Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA. schmitz@mail.med.upenn.edu

PURPOSE: The effect of exercise training on lipid peroxidation and endogenous estrogens is not well understood in premenopausal women. Exercise effects on these variables could mediate observed associations of exercise with hormonally related cancers, including breast cancer. The purpose of the study is to determine the effect of 15 weeks of aerobic exercise on lipid peroxidation, endogenous estrogens, and body composition in young, healthy eumenorrheic women. METHODS: Fifteen sedentary premenopausal women (18-25 years) participated. Pre- and post-exercise training urine collection (three 24-h samples) started 48 h after most recent exercise session for analysis of a marker of lipid peroxidation (F(2)-isoprostane) and endogenous estrogens, including 2-hydroxyestrogens, 4-hydroxyestrogens, 16-alpha-hydroxyestrone, and ratios of these metabolites (2:16, 2:4). Body composition was measured by dual-energy X-ray absorptiometry, and F(2)-isoprostanes and estrogens were measured by gas chromatography-mass spectrometry. RESULTS: Aerobic exercise resulted in a 34% decrease in F(2)-isoprostane (P = 0.02), a 10% increase in fitness (P = 0.004), a 1.2 kg decrease in body mass (P = 0.007), and a 1.8 kg decrease in fat mass (P = 0.04). No significant changes were noted in estrogens. CONCLUSIONS: The effect of exercise training on oxidative stress may be relevant to risk for hormonally related cancers.

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PMID: 18199727 [PubMed - indexed for MEDLINE]


 
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Effect of weighted exercises on bone mineral density in post menopausal women. A systematic review.

Zehnacker CH, Bemis-Dougherty A.

Physical Therapy Consults, Frederick, MD 21701, USA. doctorcz@comcast.net

PURPOSE: Osteoporosis is both preventable and treatable with exercise playing an important role in osteogenesis. The purpose of this systematic review was to determine which specific exercise programs utilizing weights were effective in maintaining or increasing bone mineral density (BMD) in postmenopausal women. METHODS: A computerized search of the MEDLINE, CINAHL, EMBASE, PEDro, and Science Citation databases was conducted for the period 1990 through February 2005. The search was performed using English language-only keyword searches using MESH terms osteoporosis, postmenopausal, exercise, weight training, and bone mineral density. A total of 20 articles was critically evaluated for the quality of an intervention study using the criteria developed by MacDermid. An expert on the topic was asked to review the list of articles for omissions. RESULTS: The review revealed evidence to support the effectiveness of weight training exercises to increase BMD in postmenopausal women. The increases in BMD were site-specific and required high loading with a training intensity of 70% to 90% of 1 RM for 8 to 12 repetitions of 2 to 3 sets performed over one year duration. CONCLUSION: Weighted exercises can help in maintaining BMD in postmenopausal women and increasing BMD of the spine and hip in women with osteopenia and osteoporosis. The exercise program must be incorporated into a lifestyle change and be lifelong due to the chronic nature of bone loss in older women.

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PMID: 18171491 [PubMed - indexed for MEDLINE]


 
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Physical functioning and menopause states.

Sowers M, Tomey K, Jannausch M, Eyvazzadeh A, Nan B, Randolph J Jr.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, USA. mfsowers@umich.edu

OBJECTIVE: To assess whether losses in physical functioning are related to the natural menopause, hysterectomy, or calendar time during midlife, after adjustment for body size and smoking. METHODS: A longitudinal assessment of physical functioning was conducted from 2000/01 through 2005/06 in a population-based sample of 544 women at midlife enrolled in the Michigan Bone Health and Metabolism Study. Longitudinal mixed models were used to relate menopausal status to measures of physical functioning. Perception of physical functioning was assessed with the Medical Outcomes Study Short-Form 36 questionnaire. Eight performance-based measures of physical functioning were also included. RESULTS: Women with hysterectomy (with or without estrogen from ovarian conservation or exogenous replacement) had reduced levels of functioning and greater rates of change in the 2-lb lift (P<.005), sit-to-stand (P<.01), timed stair climb (P<.01), timed walk (P<.01), velocity (P<.05), and perception of physical functioning (P<.01) compared with premenopausal and perimenopausal women after adjustment for time since baseline, body size, and smoking. Diminished functioning in postmenopausal women was observed in hand grip (P<.005), 2-lb lift (P<.05), sit-to-stand (P<.05), velocity (P<.05), and perceived physical functioning (P<.05). Based on regression analyses, there was greater loss in women with hysterectomy compared with natural menopause. Level of functioning among postmenopausal women with exogenous hormone replacement was similar to premenopausal women on eight of nine physical functioning measures. CONCLUSION: Hysterectomy, even with availability of an estrogen source, seems to be a "risk" state for diminishing physical function at midlife, and this may initiate a vulnerable stage for future compromised quality of life. LEVEL OF EVIDENCE: II.

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PMID: 18055722 [PubMed - indexed for MEDLINE]


 
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Resistive exercise blunts LPS-stimulated TNF-alpha and Il-1 beta.

Phillips MD, Flynn MG, McFarlin BK, Stewart LK, Timmerman KL, Ji H.

Department of Kinesiology, Texas Christian University, Fort Worth, TX 76123, USA. m.phillips@tcu.edu

To examine the influence of acute resistive exercise and "hormone status" on cytokine profile, 35 postmenopausal women (72 +/- 6.2 yr) underwent a moderate-high-intensity resistive exercise bout or rested. There were 4 groups: no hormone replacement (NHR, n = 9), hormone replacement (HRT, n = 12), selective estrogen receptor modulator (SER, n = 7), or resting control (no hormone replacement, CON, n = 7). NHR, HRT, and SER exercised (3 sets, 10 exercises @ 80 % 1RM). Blood was collected pre-exercise (PR), postexercise (PO), and two hours (2H) postexercise (same times for CON). Blood was diluted 1 : 10 in culture medium and incubated (37 degrees C, 5 % CO2, 24 h) with lipopolysaccharide (LPS, 25 microg . ml (-1)). Serum and supernatant from LPS-stimulated blood were analyzed for IL-6, IL-1 beta, and TNF-alpha using ELISA. Resistive exercise increased PO serum IL-6, and PO LPS-stimulated IL-6 and IL-1 beta in the exercise groups (HRT, NHR, SER collapsed; EX, n = 28). LPS-stimulated IL-1 beta remained elevated at 2H in EX and was significantly higher than PR in CON at 2H. Expressed per monocyte, EX had significantly lower IL-1 beta and TNF-alpha LPS-stimulated production at PO and 2H compared to CON, indicating an exercise-induced blunting of an apparent diurnal response on cytokine production. In postmenopausal women, acute resistive exercise increased circulating IL-6, but reversed an apparent diurnal increase in LPS-stimulated IL-1 beta and TNF-alpha production with no influence of hormone replacement or raloxifene.

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PMID: 17990210 [PubMed - indexed for MEDLINE]


 
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Non-estrogenic approaches for the treatment of climacteric symptoms.

Albertazzi P.

Contraception and Reproductive Health Services, Central Abacus, Liverpool, UK.

Non-estrogenic alternatives for the treatment of climacteric symptoms have their origin lost in history. Recent clinical trial data have shown that lifestyle and diet adjustment have some effect in improving both hot flushes and mood. Over-the-counter phytotherapeutic extracts are very popular and women often try a variety of products before resorting to traditional medicine. Preparations containing isoflavones in variable doses, such as soy extract and red clover, or extracts from evening primrose, Cimifuga racemosa, ginseng and black cohosh are often used for treating the climacteric syndrome. The scientific support for their efficacy certainly does not equal their popularity. The most tested pharmacological alternatives to estrogens are serotonin reuptake inhibitors (SSRIs). All available SSRIs have undergone trials for the relief of hot flushes. In spite of the difference between the compounds in both half-life and engagement of serotonin receptors, they appear to have very similar effectiveness in reducing hot flushes. At their best, SSRIs reduce hot flushes by 50-60%, compared with 80% for estrogen, and their effect appears only in the short term. SSRIs have mood-improving effects that appear to be independent of the effect on hot flushes. When used for the treatment of the climacteric syndrome, SSRIs do not adversely affect libido. Dependence is a major concern in women when offered this type of treatment, but does not appear to be a problem with this class of drugs. Withdrawal symptoms have never been reported in trials for hot flushes but are known to occur when SSRIs are used in the long term. In order to avoid these symptoms, the dose should be tapered slowly. Gabapentin, a drug used for the treatment of neuropathic pain and epilepsy, has shown that, in high doses, it has an efficacy similar to that of estrogen; however, this needs further confirmation.

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PMID: 17882686 [PubMed - indexed for MEDLINE]


 
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Exercise in the menopause - an update.

Pines A, Berry EM.

Department of Medicine T, Ichilov Hospital, Tel-Aviv, Israel.

One of the most important components of lifestyle relates to physical activity. Sedentary people fare less well than those who exercise regularly. The benefits of exercise can be demonstrated in many organs of the body. The most frequently studied effect of exercise is reduction in cardiovascular morbidity and mortality, but positive effects on the musculoskeletal system, breast cancer, mood and cognition, and quality of life have been recorded as well. In many cases, a dose-response was evident, and even a mild to moderate degree of activity, performed only a few times weekly, may carry significant merits. The following article reviews this topic and brings updated information on the benefits of exercise on postmenopausal health.

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PMID: 17882672 [PubMed - indexed for MEDLINE]

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Effects of additional resistance training during diet-induced weight loss on bone mineral density in overweight premenopausal women.

Nakata Y, Ohkawara K, Lee DJ, Okura T, Tanaka K.

Institute of Health and Sport Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305-8577, Japan. nakata@stat.taiiku.tsukuba.ac.jp

Bone loss accompanies a diet-induced weight loss and could be prevented with a combination of exercises. This study was conducted to examine the effects of additional resistance training during diet-induced weight loss on whole-body and selected regional bone mineral density (BMD). The participants of a 14-week weight-loss study were 42 overweight premenopausal Japanese women who were randomly placed in either a diet-only group (D; n = 21) or a diet plus resistance training group (DR; n = 21). Whole-body BMD and body composition, lumbar spine BMD, and 1/3 radial BMD were measured by dual-energy X-ray absorptiometry before and after the intervention. Bone formation and resorption markers were also measured. Thirty-five participants (83%) completed the study. Individuals in groups D (n = 17) and DR (n = 18) lost 6.2 +/- 3.5 kg and 8.6 +/- 3.6 kg body weight, respectively. Reductions in percentage fat mass and fat mass in group DR were significantly greater than in group D; lean mass decreased significantly in both groups. The effect of time on whole-body BMD was significant (-0.3%); however, whole-body bone mineral content, lumbar spine BMD, and 1/3 radial BMD remained unchanged. There were no significant timeby-group interactions in the whole-body and regional BMD and bone markers. These results suggest that additional resistance training during weight loss has no effect on BMD in overweight premenopausal Japanese women. Further long-term studies with large numbers of subjects are needed.

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PMID: 18301974 [PubMed - indexed for MEDLINE]


 
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Does high-intensity resistance training maintain bone mass during moderate weight loss in older overweight adults with type 2 diabetes?

Daly RM, Dunstan DW, Owen N, Jolley D, Shaw JE, Zimmet PZ.

Center for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Melbourne, Australia. rmdaly@deakin.edu.au

The aim was to investigate whether the addition of supervised high intensity progressive resistance training to a moderate weight loss program (RT+WLoss) could maintain bone mineral density (BMD) and lean mass compared to moderate weight loss (WLoss) alone in older overweight adults with type 2 diabetes. We also investigated whether any benefits derived from a supervised RT program could be sustained through an additional home-based program. This was a 12-month trial in which 36 sedentary, overweight adults aged 60 to 80 years with type 2 diabetes were randomized to either a supervised gymnasium-based RT+WLoss or WLoss program for 6 months (phase 1). Thereafter, all participants completed an additional 6-month home-based training without further dietary modification (phase 2). Total body and regional BMD and bone mineral content (BMC), fat mass (FM) and lean mass (LM) were assessed by DXA every 6 months. Diet, muscle strength (1-RM) and serum total testosterone, estradiol, SHBG, insulin and IGF-1 were measured every 3 months. No between group differences were detected for changes in any of the hormonal parameters at any measurement point. In phase 1, after 6 months of gymnasium-based training, weight and FM decreased similarly in both groups (P<0.01), but LM tended to increase in the RT+WLoss (n=16) relative to the WLoss (n=13) group [net difference (95% CI), 1.8% (0.2, 3.5), P<0.05]. Total body BMD and BMC remained unchanged in the RT+WLoss group, but decreased by 0.9 and 1.5%, respectively, in the WLoss group (interaction, P<0.05). Similar, though non-significant, changes were detected at the femoral neck and lumbar spine (L2-L4). In phase 2, after a further 6 months of home-based training, weight and FM increased significantly in both the RT+WLoss (n=14) and WLoss (n=12) group, but there were no significant changes in LM or total body or regional BMD or BMC in either group from 6 to 12 months. These results indicate that in older, overweight adults with type 2 diabetes, dietary modification should be combined with progressive resistance training to optimize the effects on body composition without having a negative effect on bone health.

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PMID: 15937634 [PubMed - indexed for MEDLINE]


 
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Bone mineral density during reduction, maintenance and regain of body weight in premenopausal, obese women.

Fogelholm GM, Sievänen HT, Kukkonen-Harjula TK, Pasanen ME.

UKK Institute for Health Promotion Research, Tampere, Finland. mikael.fogelholm@helsinki.fi

Weight loss may lead to bone loss but little is known about changes in bone mass during regain of reduced weight. We studied changes in bone mineral density (BMD) and bone mineral content (BMC) during voluntary weight reduction and partial regain. The study consisted of three phases: a 3 month weight reduction with very-low-energy diet (VLED), a 9 month randomized, controlled walking intervention period with two training groups (target energy expenditure 4.2 or 8.4 MJ/week) and a 24-month follow-up. The participants were premenopausal women with a mean body mass index of 34.0 (SD 3.6) kg/m2. Seventy-four of 85 subjects completed the whole study. Total body, lumbar spine, proximal femur and dominant radius BMD and BMC were measured with dual-energy X-ray absorptiometry (DXA). The mean weight loss during VLED was 13.2 (3.4) kg, accompanied by unchanged total body BMC and decreased lumbar, trochanteric and radial BMD (p < 0.05). During months 3-36, an average of 62% of the weight loss was regained, total body BMC decreased and trochanteric BMD increased (p < 0.05). At the end of the study, total body BMC and lumbar and femoral neck BMD were lower than initially (p < 0.05). Weight change throughout the study correlated significantly with the change in radial (r = 0.54), total body (r = 0.39) and trochanteric (r = 0.37) BMD. Exercise-group assignment had no effect on BMD at weight-bearing sites. In conclusion, the observed changes in BMD and BMC during weight reduction and its partial regain were clinically small and partly reversible. More studies are needed to clarify whether the observed weight changes in BMD and BMC are real or are artifacts arising from assumptions, inaccuracies and technical limitations of DXA.

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PMID: 11315238 [PubMed - indexed for MEDLINE]


 
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Erratum in:
  • Am J Clin Nutr. 2007 Sep;86(3):808.


Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake.

Riedt CS, Schlussel Y, von Thun N, Ambia-Sobhan H, Stahl T, Field MP, Sherrell RM, Shapses SA.

Rutgers University, New Brunswick, NJ, USA.

BACKGROUND: Weight loss is associated with bone loss, but this has not been examined in overweight premenopausal women. OBJECTIVE: The aim of this study was to assess whether overweight premenopausal women lose bone with moderate weight loss at recommended or higher than recommended calcium intakes. DESIGN: Overweight premenopausal women [n = 44; x (+/-SD) age: 38 +/- 6.4 y; body mass index (BMI): 27.7 +/- 2.1 kg/m(2)] were randomly assigned to either a normal (1 g/d) or high (1.8 g/d) calcium intake during 6 mo of energy restriction [weight loss (WL) groups] or were recruited for weight maintenance at 1 g Ca/d intake. Regional bone mineral density and content were measured by dual-energy X-ray absorptiometry, and markers of bone turnover were measured before and after weight loss. True fractional calcium absorption (TFCA) was measured at baseline and during caloric restriction by using a dual-stable calcium isotope method. RESULTS: The WL groups lost 7.2 +/- 3.3% of initial body weight. No significant decrease in BMD or rise in bone turnover was observed with weight loss at normal or high calcium intake. The group that consumed high calcium showed a strong relation (r = 0.71) between increased femoral neck bone mineral density and increased serum 25-hydroxyvitamin D. No significant effect of weight loss on TFCA was observed, and the total calcium absorbed was adequate at 238 +/- 81 and 310 +/- 91 mg/d for the normal- and high-calcium WL groups, respectively. CONCLUSION: Overweight premenopausal women do not lose bone during weight loss at the recommended calcium intake, which may be explained by sufficient amounts of absorbed calcium.

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PMID: 17413095 [PubMed - indexed for MEDLINE]


 
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Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study.

Lohman T, Going S,